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You have to spike them through the head if they are a zombie. That or shoot them with a Z Max projectile.

I can confirm that when you gut shoot a rabbit with a 223 and a vmax it's dead. Not saying anybody should gut shoot rabbits but it's more insurance for when you don't hit it in the right place. ...

I think the best killing 22 ammo is the all lead (as opposed to copper washed) projectiles with the biggest hollow point possible. This generally means subsonics which are also the most accurate...