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Yes shot a fallow deer with one a while back, base of neck at about 60-70 yards so not much of a test, died on the spot. I don't think they shoot as well in my rifle as the lighter bullets.
I think...

I run 36 grs of 2208 with the 55gr Noslar BT for 3588 fps average. Shoots good in my Rem SPS with a 24 inch barrel.