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Using the ELD-M or Berger hunting bullets I don't tend to aim for the foreleg/shoulder, I aim just a bit further back into the ribs as in my experience these bullets penetrate a 2" (87gr) -4" (105gr)...

According at alliants load date RL26 will push 105gr bullets to over 3000 fps from a standard 243.
I'm getting just on 3000 fps from mine and 0.7 gr under their max. will note that it's a cheap...