You will probably have far too much case capacity.
308 is okay with 180+ grain projectiles 150gr do not seat deep enough and require too little powder to have good case full for subs with trailboss. 56grain water vs ~80 grains for 300wsm. Even with 220 grain pills you will more than likely be well below 50%.
I have no experience with fillers so cant comment on that.
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