Like @distant stalker said. The 2225 powder is better with the heavier projectiles or already that's what I have found.
I have a 7/300wsm (different obviously, but very similar in internal capacity), I have found my upper limit with the 2225 and a 180 berger. The load is slightly compressed from memory.
I used to use 2213sc with lighter .277" projectiles in the 270wsm
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