Originally Posted by
Mauser308
I never bothered trying to kill them. They are coated in a layer of sealant to protect the priming compound from oxidation and contamination, and it usually does it's job really well. It's actually quite an effort to reliably kill off a bunch of primers.
My advice is pull projectile and remove powder charge, and either decap live and treat with appropriate respect - or inert them by chambering the empty primed case, pointing in a safe direction and discharging into some old towels or similar. Note with the second method you are still going to get a bang and high speed projected gasses and debris from the priming compound, so hearing protection, eye protection, and neighbour protection (so you don't end up with a visit).