if your serious about varminting, then barrel life needs to be considered.
In 0.224 cal a 22-250 will give you 1200-1500 rounds before your throat and accuracy goes south.
In 6mm cal a 243/creedmore case capacity is not gong to give you much more with light projectiles and full powder charges. Thats why Tubbs developed the 6 XC with smaller case capacity
By comparison a 6mmBr will give you 3000-4000 rounds before accuracy starts to go. 6mmBr will push the 87vM at 3100fps which is pretty close to what you get from 243.
If your considering 6mm then 6.5*47 or 6mm XC is better case to build on.
Other point to remember is varmints are small light framed animals, so non plastic tipped projectiles dont work! i.e. bergers. Once you go to 6mm you there is only one vld type projectile that works (105AM) all the other 95+ vlds drill straight through.
I'm just doing load dev on a 22Br shooting 75 AM. Can get to 3300fps with no pressure signs. Havnt been in field with it yet but the 0.224 75 AM has hight bc than 6mm 87 VM and that explosive from 50-400m so expect the 75 AM to have similar terminal performance but shoot flatter and better in wind.
Hotbarrels comments about recoil are also very relevant. Half the fun with varminting is seeing the hits. 204 is magic, 20Br has enough extra recoil to loose your sight picture if not a heavy gun.
Cheers
grant
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