Copper or nickel antisieze on the threads, and that helps stop the crap from combustion getting into the threads and seizing them up. I'd run with the nickel myself just with the alloy threads from personal preference but that's just me. The other issue is with a hot can after firing the threads can work up really tight, gently warming the thing up with a few shots haha can help you spin them apart. The makers often supply clampy thingies to help you grab and unscrew them.
As far as cleaning a sealed can, an ultrasonic cleaner is one way - I wouldn't fill it with solvents after seeing what happened to one that the owner drowned in petrol. Let it drip dry and a few hours later put a shot through expecting everything to have evaporated. I think the conclusion was that there was still a bit of petrol remaining in it, and the resulting pop blew a nifty split down one side. Rooted it...
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