Something based on WSM or SAUM or a single shot based on a RUM (i.e 338 Edge) would be the easiest. Or you could open it up to a .585 boltface (if that is an option with your action) and do something based off a 338LM case or a Norma Magnum case.
For me: easiest 7mmSAUM or a 7mm/300WSM (using Norma brass)
Then possibly: 338 Edge single shot
If opening it up: 7mm FatMax (I have to say that as I have one) or a 338LM Improved variant, or if you are keen, a 338 Thor.
I wouldn't do a 6.5 WSM personally. Very hard on barrels from what I've heard...
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