If you are going to mainly target shoot (steel and or paper) and you plan to shoot a lot then 6.5CM, 223, 308, 243 etc make sense
Big magnums are fine but expensive to run and if shot a lot recoil becomes an issue.
If mainly for hunting then what ever floats your boat but personally a larger calibre heavy bullet going at moderate speed seems the most consistant in performance at least for me.
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