A mate of mine did up subs in a .280 using trail boss, so can be done. He found that he could not get projectiles to open up on goats/deer and gave up on the the project. He just uses them now for dealing with camp possums. That was a decade or so ago, so may be a better selection of projectiles...although I can't imagine that .270 cal is well supported in this regard.
I like @Micky Ducks idea, try a frangible varmit style bullet at low (but still supersonic) speed with Trail boss, I reckon you could get great results and still be a lot quieter than standard ammo.
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