I started out culling goats (not for a living more just because i was asked to) with a 222 that worked well as I became more confident and consistant I moved to 22 hornet. Im not suggesting going culling with a 22lr but saying that it has been done. The times Ive shot them myself with 22lr were when thats what i was carrying at the time. If components were more available id probably use the grendel more. What ever you decide to use use it within its limitations.
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