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Yea I did with trail boss, and 45gr hornet projectile, don't remember speeds, but guessing around 2500ish, sure I seen load data for 22-250 on hodgdon site,
also built a few loads with SR4759, and...

I have had two, and at sum point will get another, esp if I move back down south. great open country varmint round, and with suitable bullets, 60gr partion, 64 gr soft point win, or any of the a-max...