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Can’t speak for the 7x64 or standard 280, but for 280ai the answer is YES. I got more than 100 fps gain. I imagine you should see similar gains in the standard cartridges.

Did some load dev for 7x64 back a while now, 2213 was too fast (hit pressure before getting decent speeds), RL19 and 2217 better but knowing what I know now having done load dev for 280AI I’d be...

N560 works a treat in my 280ai

staggering difference between RL 25 & 26 .... seems weird.
I thought Alliant stated when they introduced RL 26 & 23, that these were just more temp stable versions of 25 and 22 ?? really ?

Yep 280AI, 24 in bbl. very similar load from memory right around 60gn N560

Not yet, switched from RL22 to N560 and got an extra 100 fps (now 2980 fps with the old 162 AMAXs) Have a couple of bottles of N560 to burn thru