For example this gentleman has done a tremendous amount of testing different loads using the usual methods, powder charge and seating depths - and doing a heap of faff like weight sorting brass and bullets - and every single one of the groups shot during the "development" process just falls within the cone of fire he gets when he actually shoots 20rd of his "optimised" load - which he ultimately isn't happy with
https://youtu.be/BSjTbf26EpA?si=0hhmMNaGCP4ilN2z
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