I would recon the twist rate affect the stability of a given weight of bullet. If the bullet is unstable, then it will affect the BC for that bullet. But I am not convinced the ballistic apps are that advanced to consider whether the twist rate for your selected bullet will be optimal or not and therefore the ballistics will be calculated accordingly - but I might underestimate how advanced they are.
I had a big discrepancy between the Shooter app and the 4Dof calculator. Turned out the 4Dof calculator was more correct and that the Shooter app had some crazy factor it applied if you turned spin drift and coriolis compensation on. Nowadays I just use StelokPro - seem to be the most trustworthy for me.
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