Cheers for the replies guys,
I arrived at 46.5 gr mostly due to velocity, as group size did not vary much at all on the basis of powder charges. I imagine this is purely because I haven't got the seating depth right though, as horihunter said, that will probably be the main source of error.
Interesting read on the BallisticStudies site, I'd looked at the 185gr pill as an option but chose the 190 purely due to higher B.C.
On an unrelated note, I shot a hare with this load a few weeks back @50m, which very surprisingly didn't die straight away. It was a lower chest shot, and I had to give it a coup de grace.. This was the first time I'd had to finish off a hare after shooting it with the .308
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