define "lots of room left" from my understanding of things the fuller the better to be sure BUT above say 70% is pretty normal and fine...IF you get less than 50-60% fill you can get flame from primer flash over top of powder which causes issues and a chance of secondary explosion....which i belive is when it goes baboom...had that with low charge of 760 in .270 years back with loads done for me by sports shop....I had to point rifle at sky and lower onto target to prevent it happening...wasnt flash I tell you.
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