If there is lots of space left in the case it can cause inconsistent ignition.
Picture a case only half full of powder. Depending on the angle of the rifle/cartridge, all the powder within the case could all go to one end or the other, or sit with more at one end than the other etc etc etc. This can cause inconsistency in ignition between the powder & primer. For example in a half full case - sometimes powder will be right up against the primer, and other times all the powder might be at the front of the case with a big gap between powder & primer.
The less the powder can move around in the case, the less potential there is for inconsistency caused by difference in the powder column & how it is ignited by the primer.
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