In my experience Subs are for well placed heart, spine, neck or head shots ONLY
Unlike a 22, 30 cal subsonics will destroy whole sections of the spine and skull resulting in an instant death but heart shots will take a few moments to drop the animal.
If you don't think you can do that reliably use only high velocity.
Haven't tried 45/70 Leighi or anything fancy only lead projectiles.
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