Starting at 52/55 grain - which are good enough - the killing effectiveness at increasing ranges exponentially improves so long as you can hold the velocity up. Soft bullets are fine (the curved ball are the lighter mono's but generally they are best at the shorter ranges). Peak effectiveness seems to be reached at 70-80 grains held at over 2800 fps MV. By then you are getting out to ranges you would have traditionally reserved for the likes of the .243. Not that a comparison should be made . 'Cos if you are using a .223 bigger calibers aren't in the frame at the time of squeezing the trigger. That's my take on it.
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