On the ballistics calculator it just craps all over my .223 loads. But in saying that, I have and witnessed others pull off some amazing shots with .223's. I've only shot one deer with a .223, but I've shot tons of goats and it just smashes them with the right bullets. I wouldn't feel undergunned if I could only have a .223. It's cheap, accurate and effective if you understand it's limitations. Grendel is expensive and much higher performance. You don't want to lose any brass.
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