Thinner skinned animals and I am inclined to agree. It is like buying faster 22LR. In most cases subs (22) will go straight through a rabbit and a super just goes through faster. But with more stubborn animals I have found the bigger bullets more like hitting it with a bigger hammer.
When trying to remain subsonic, the only limit is speed. So to carry more energy further you need more weight. If you have sufficient energy then more weight is not needed. A 150gr traveling at the same speed as a 220gr will not carry the same energy. I used the Hornady ballistic calculator and by pushing it all the way out to 250 yards (way more than I would ever use a sub 30cal) I found the trajectory difference is negligible, velocity difference is remarkably closer than I expected as well, but energy retained remains considerably higher on the heavier bullet as to be expected. As mentioned, on soft game like goats this is not really a problem, but on heavier set game like a sturdy bush stag or ornery boar, I think I would go for the heavier bullet. For penetration in these cases a copper jacketed "normal" projectile would work but so too would a harder compound lead. With lead you can control the amount of softness so it mushrooms / distorts quickly (soft) or holds its shape for penetration (hard).
All will work, and whatever you decide you want to use then the beauty of handloading is you can load exactly what you prefer. For subs I prefer a large 220gr at around 1000fps and from what I have seen it works "up close and personal" in scrub. You are also correct that accuracy is still key and if you are having success with 150s then a 150 that hits its target will be more effective than any 220 that misses.
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