The biggest difference for me going from, macpac, Tontoka, osprey, expeed and going to the exo was getting the weight off my shoulders' and back,
The weight sits on my hips and can feel it on my legs
I have only had mine up2 45kg but i was fine the next day.
I have major back issues ( was told i would never carry a backpack again) and would normally be crippled after carrying that much.
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