With bigger cals and also with stouter projectiles in medium cals where the projectile passes through, I believe there is a Venturi effect that sucks fluid out of the wound helping to depressurise the vascular system. Certainly using Accubonds in my 270 I nearly always find globs of blood on the ground. This does not come from blood bleeding out of the animal but is there instantly the bullet passes through. Often animals run a short distance on a hit with an AB, but there will be blood behind where they were standing and normally 1-2 tablespoons full.
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