The principal requirement of a suppressor is for it to have enough internal volume to contain and dissipate the gases produced. The gases are proportional to the amount of powder burned. A .38 Special cartridge would have at least four times more powder than a .22 LR, therefore you would need a suppressor with four times the internal volume to be effective. You could drill out a .22 suppressor to suit and it would reduce the sound a little bit, subject to staying in one piece, but the standard 1/2" UNF thread is not suitable for the .38 as the barrel wall would be too thin to be reliable.
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