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Yep my chronograph has "ruined" 1 or 2 "good" groups (100 yds) where the measurement was sub 0.5moa but the ES and SD where too big meaning that for my long range work the load was unacceptable.

The only cartridge I use 760 in is my 6.5x55ai.
Have done that since the first shot in an experiment to see what the barrel life will end up at, given that 760 burns at a lower temp.
Accuracy is...