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The pressure limit is kept at like 53,000psi in the manufacturer data, because the AR15's that shoot it have weaker bolts than their 223 equivalents. In a bolt gun, you can push it a bit harder.
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Really comes down to personal preference. Do you prefer fast and light or heavy and slow?

Grendel was designed to maximise the range of the AR platform. With that in mind, a heavy high BC bullet...