My action is a Mk5 Wby,very strong! with a P17, you would not look to go too far in the red zone with your loads, but as a general guide, one of the indicators I look for is the extractor mark rather than primers, they can indicate over pressure when there is none (unless they are falling out the pocket of course!) Without a strain gauge of my own, it is a little subective, but I use the ADI max as a starting point and go up or down from there looking for the best blend of outright velocity and accuracy - but you really do need to chrony your loads. 25" is a good length for 2506, any shorter is a complete waste, might as well be running a .257 Roberts!. I have a suppressor but seldom use it-(earmuffs on the range) but would if I were bombing up as you are.
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