Greetings Thatguy,
The reason for the low 250 grain load is the hard projectile that Hodgdon is using in their data. Winchester gave loads of 34 and 36 grains for a 260 grain jacketed soft point and suggested it not be reduced due the possibility of squib loads. The differences are solely due to the hardness of the projectile. If and only if your 250 grain projectile is a softer jacketed type like the JSP you can work up to the loads for the 260 grain. These days projectile of the same weight but different construction often need quite different loads. You might like to go back and re read my earlier posts.
Regards Grandpamac.
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