@Magnetite, kinda depends on what you want to achieve.
For most shooting (service rifle, gongs, hunting) I just load using Federal.
When I shot fullbore and was looking for the last ounce off accuracy, I did full load dev with 3 different primers. They can make a surprising difference to your SD values. RWS primers were by far the best I tested, followed by Fed Match and CCI BR.
In general, powder and or primer will give you speed consistency. Seating depth gives you group size variation within that.
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