TLDL: (if I listened correctly)
Seat bullet 25 - 35 thou off lands (although this not really important)
Choose bullet appropriate for your purpose (maybe have second and third choice)
Choose powders that will push bullet at MV required to do what you are trying to do
Shoot 10 shot groups with your bullet of choice but with different powders
Choose best groups, shoot 20 shot groups of each.
If still unhappy, change bullet, repeat.
If still unhappy, change barrel or change expectations.
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