If you look at what most deer are shot with out to 300-400yrds. It seems a bullet weight of 100-150gns traveling somewhere between 2700-3000fps with an average bc would some up whats most commonly used. Most of the new cartridges match and/ or barely improve on the old tried and true so don't be fooled. Look at what ever caliber you like that perform in the above parameters and you will be fine. I'd say somewhere in the middle, 120-140gn around 2800-2900fps and job done. Doesn't matter what caliber throws it. A 140 grain bullet at 2800fps with an average bc will perform the same as one of similar weight out of a bigger or smaller hole with a similar speed and similar bc and construction.
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