If you are reloading, I'd go 30-06
Would give you a nice heavy hitter, compared to the 243. Very versatile caliber that shoots a massive range of projectile weights comfortably.
I'd also leave the barrel long to gain maximum potential.
You've covered:
varmint - 223
general hunting - 243
bush basher : 44/40
so the one side you are missing is longer range hunting rifle with good knockdown power.
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