22BR is what I'm seriously considering for the heavy 22 cal projectiles. Lapua brass in a no neck turn chamber. (Marginally) Less work than the 22-250AI and better barrel life. Giving up a little performance though so need to decide what is most important. In a 6mm I'd be looking hard at a 6mmBRA or 6mm Creedmoor.
The other option that I'm looking at is a 224 Valkyrie, but that requires a different bolthead. If there was Lapua (or Lapua quality) brass available I'd be all in. The 75gr ELD-M needs a 1 in 8 twist, its a real eye opener to run the numbers on this at 2,900fps vs my 20 Tac pushing a 40gr vmax at 3,900fps (which is basically the same ballistically as a 22-250 with 50/55gr projectiles). 40gr is subsonic just after 700m, 75gr is still supersonic at 1k! and massively better in the wind. Pretty hard to beat the splat factor of the fast projectiles out to 300-400m but then BC and weight really take over.
I don't want to do anything on a 223 case as I already form 223 down to 20 Tactical so another chambering on the same brass is out of the question for me, just to avoid potential headaches (or worse!) with brass mix ups...
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